Dr. Jayne Henry, a talented British archaeologist, is leading the restoration of Florence, Italy’s iconic Basilica of the Santissima Annunziata, when she uncovers a stunning secret—Leonardo da Vinci's fabled lost studio. This groundbreaking find threatens to reshape history, prompting the Italian Historical Society to halt the project and exclude foreign involvement. Sidelined yet determined, Jayne embarks on a quest to retrace Leonardo's steps across Renaissance Europe to uncover the truth. Her focus shifts to a young Leonardo, who, at 28 years old, is burdened by debt and stuck in creative despair. His destiny changes when he meets a captivating woman who reignites his imagination on a streak of creativity the world has never seen. The untold tale behind the smile of the mysterious Mona Lisa is pieced together, unlocking the secrets of the past and presenting Jayne with a new perspective on her own future.